Drug search by name

Rifadin IV Intravenous and Tolazamide

Determining the interaction of Rifadin IV Intravenous and Tolazamide and the possibility of their joint administration.

Check result:

Rifadin IV Intravenous <> Tolazamide

Relevance: 26.09.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

RifAMPin may decrease the blood levels of TOLAZamide, which may make the medication less effective in treating diabetes. Monitor your blood sugar levels closely. You may need a dose adjustment of TOLAZamide during and after treatment with rifAMPin. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Rifampin may increase the metabolism of the oral sulfonylureas. The therapeutic effects of sulfonylureas may be decreased. The mechanism is induction of CYP450 hepatic isoenzymes. A similar reaction is possible with rifabutin.

MANAGEMENT: Patients on concomitant therapy should be monitored for loss of blood glucose control. Sulfonylurea dosage may need to be increased. The clinician should also be alert for hypoglycemia after a rifamycin is discontinued.

References

Borcherding SM, Baciewicz AM, Self TH "Update on rifampin drug interactions." Arch Intern Med 152 (1992): 711-6
"Product Information. Mycobutin (rifabutin)." Pharmacia and Upjohn, Kalamazoo, MI.
Kihara Y, Otsuki M "Interaction of gliclazide and rifampicin." Diabetes Care 23 (2000): 1204-5
"Product Information. Rifadin (rifampin)." Hoechst Marion-Roussel Inc, Kansas City, MO.
Self TH, Morris T "Interaction of rifampin and chlorpropamide." Chest 77 (1980): 800-1
Venkatesan K "Pharmacokinetic drug interactions with rifampicin." Clin Pharmacokinet 22 (1992): 47-65
Strayhorn VA, Baciewicz AM, Self TH "Update on rifampin drug interactions, III." Arch Intern Med 157 (1997): 2453-8
Self TH, Tsiu SJ, Bowld WF, Fowler JW "Interaction of rifampin and glyburide." Chest 96 (1989): 1443-4

Rifadin IV Intravenous

Generic Name: rifampin

Brand name: Rifadin IV, Rifadin, Rimactane

Synonyms: Rifadin IV (Intravenous), Rifadin IV

What is Rifadin IV Intravenous?

Tolazamide

Generic Name: tolazamide

Brand name: Tolinase

Synonyms: TOLAZamide

What is Tolazamide?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions