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Rifampin and Silenor

Determining the interaction of Rifampin and Silenor and the possibility of their joint administration.

Check result:

Rifampin <> Silenor

Relevance: 02.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Rifampin may decrease the serum concentration of tricyclic antidepressants and their therapeutic effects. The proposed mechanism is metabolic induction. The clinical significance is unknown. Dosage adjustments may be required if an interaction is suspected.

References

Bebchuk JM, Stewart DE "Drug interaction between rifampin and nortriptyline: a case report." Int J Psychiatry Med 21 (1991): 183-7

Rifampin

Generic Name: rifampin

Brand name: Rifadin, Rifadin IV, Rimactane

Synonyms: n.a.

What is Rifampin?

Silenor

Generic Name: doxepin

Brand name: Silenor, Sinequan, Sinequan

Synonyms: n.a.

What is Silenor?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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