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Rifampin Capsules and Theo-Dur

Determining the interaction of Rifampin Capsules and Theo-Dur and the possibility of their joint administration.

Check result:

Rifampin Capsules <> Theo-Dur

Relevance: 11.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using rifAMPin together with theophylline can decrease the effects of theophylline. You should be advised to notify your doctor if you experience a worsening of breathing problems. You may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Rifampin may decrease the plasma concentrations of theophyllines by inducing CYP450 3A4 and 1A2 hepatic metabolism.

MANAGEMENT: While receiving rifampin, patients should be monitored for changes in theophylline serum concentrations or inadequate response to theophylline. Patients should be advised to notify their physician if they experience a worsening of their respiratory symptoms. Dosages should be adjusted as necessary.

References

Dal Negro R, Turco P, Trevisan F, De Conti F "Rifampicin-isoniazid and delayed elimination of theophylline: a case report." Int J Clin Pharmacol Res 8 (1988): 275-7
Venkatesan K "Pharmacokinetic drug interactions with rifampicin." Clin Pharmacokinet 22 (1992): 47-65
Strayhorn VA, Baciewicz AM, Self TH "Update on rifampin drug interactions, III." Arch Intern Med 157 (1997): 2453-8
Upton RA "Pharmacokinetic interactions between theophylline and other medication (Part I)." Clin Pharmacokinet 20 (1991): 66-80
Borcherding SM, Baciewicz AM, Self TH "Update on rifampin drug interactions." Arch Intern Med 152 (1992): 711-6
Boyce EG, Dukes GE, Rollins DE, Sudds TW "The effect of rifampin on theophylline kinetics." J Clin Pharmacol 26 (1986): 696-9
Boyce EG, Dukes GE, Rollins DE, Sudds TW "The effect of rifampin on theophylline kinetics." Clin Pharmacol Ther 37 (1985): 183
Powell-Jackson PR, Jamieson AP, Gray BJ, et al "Effect of rifampicin administration on theophyllin pharmacokinetics in humans." Am Rev Respir Dis 131 (1985): 939-40

Rifampin Capsules

Generic Name: rifampin

Brand name: Rifadin, Rifadin IV, Rimactane

Synonyms: Rifampin

What is Rifampin Capsules?

Theo-Dur

Generic Name: theophylline

Brand name: Elixophyllin, Theo-24, Respbid, T-Phyl, Aerolate III, Slo-Bid Gyrocaps, Slo-Phyllin, Theobid, Theo-Dur, Theolair, Theovent, Bronkodyl, Theo-X, Theo-Time, Theochron, Slo-Phyllin 125, Theoclear LA-130, Aerolate JR, Theolair-SR, Theoclear LA-260, Quibron-T, Quibron-T/SR, Uniphyl, Uni-Dur, Aerolate SR, Slo-Phyllin 80, Theoclear-80, Theo-Dur Sprinkles, Theosol-80, Asmalix, Aquaphyllin, Truxophyllin, Slo-Phyllin 250, TheoCap

Synonyms: Theo-Dur (Oral)

What is Theo-Dur?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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