Rifampin Capsules and Zyvox (Linezolid Suspension)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using rifAMPin together with linezolid can decrease the effects of linezolid. Contact your doctor if your condition worsens. You may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with rifampin may decrease the plasma concentrations of linezolid. The mechanism of interaction is unknown. In eight healthy subjects, coadministration of a single 600 mg intravenous dose each of rifampin and linezolid resulted in reductions of linezolid concentrations by 10%, 20% and 35% at 6 hours, 9 hours and 12 hours postdose, respectively, compared to administration of linezolid alone.

MANAGEMENT: The potential for diminished pharmacologic effects of linezolid should be considered during coadministration with rifampin.

Rifampin Capsules

Generic Name: rifampin

Brand name: Rifadin, Rifadin IV, Rimactane

Synonyms: Rifampin

What is Rifampin Capsules?

Zyvox (Linezolid Suspension)

Generic Name: linezolid

Brand name: Zyvox

Synonyms: Zyvox

What is Zyvox (Linezolid Suspension)?