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Rifampin Intravenous and Seconal Sodium

Determining the interaction of Rifampin Intravenous and Seconal Sodium and the possibility of their joint administration.

Check result:

Rifampin Intravenous <> Seconal Sodium

Relevance: 15.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Rifampin may decrease the plasma concentrations of barbiturates by inducing hepatic metabolism. When given concomitantly with rifampin, patients should be monitored for inadequate response to barbiturates or decreases in serum concentrations, with dosages adjusted as necessary.

References

Venkatesan K "Pharmacokinetic drug interactions with rifampicin." Clin Pharmacokinet 22 (1992): 47-65
Smith DA, Chandler MH, Shedlofsky SI, Wedlund PJ, Blouin RA "The effects of rifampin induction on the stereoselective metabolism of hexobarbital in the young and elderly." Pharmacotherapy 9 (1989): 183
Richter E, Breimer DD, Zilly W "Disposition of hexobarbital in intra- and extrahepatic cholestasis in man and the influence of drug metabolism-inducing agents." Eur J Clin Pharmacol 17 (1980): 197-202
Baciewicz AM, Self TH "Rifampin drug interactions." Arch Intern Med 144 (1984): 1667-71

Rifampin Intravenous

Generic Name: rifampin

Brand name: Rifadin, Rifadin IV, Rimactane

Synonyms: Rifampin

What is Rifampin Intravenous?

Seconal Sodium

Generic Name: secobarbital

Brand name: Seconal Sodium, Seconal

Synonyms: n.a.

What is Seconal Sodium?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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