Rifampin Oral, Intravenous and Sitagliptin and metformin
Determining the interaction of Rifampin Oral, Intravenous and Sitagliptin and metformin and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.MONITOR: Coadministration with rifampin may increase the gastrointestinal absorption and therapeutic efficacy of metformin. The mechanism may involve rifampin-mediated induction of the organic cation transporter 1 (OCT1) in the gastrointestinal tract. MANAGEMENT: Until more information is available, caution is advised if rifampin and metformin are used concomitantly. Close clinical monitoring of glycemic control is recommended following initiation or discontinuation of these drugs, and the dosage of metformin may be adjusted as necessary. References Cerner Multum, Inc. "Australian Product Information." O 0 Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Professional:MONITOR: Coadministration with rifampin may increase the gastrointestinal absorption and therapeutic efficacy of metformin. The mechanism may involve rifampin-mediated induction of the organic cation transporter 1 (OCT1) in the gastrointestinal tract.
MANAGEMENT: Until more information is available, caution is advised if rifampin and metformin are used concomitantly. Close clinical monitoring of glycemic control is recommended following initiation or discontinuation of these drugs, and the dosage of metformin may be adjusted as necessary.
- Cerner Multum, Inc. "Australian Product Information." O 0
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: rifampin
Brand name: Rifadin, Rifadin IV, Rimactane
Synonyms: Rifampin
Generic Name: metformin / sitagliptin
Brand name: Janumet, Janumet XR
Synonyms: Metformin and sitagliptin, Sitagliptin and Metformin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Rifampin Oral, Intravenous-Sitagliptin and Metformin Extended-Release Tablets
- Rifampin Oral, Intravenous-Sitagliptin and Metformin Tablets
- Rifampin Oral, Intravenous-Sitagliptin and simvastatin
- Rifampin Oral, Intravenous-Sitagliptin Phosphate
- Rifampin Oral, Intravenous-Sitavig
- Rifampin Oral, Intravenous-Sivextro
- Sitagliptin and metformin-Rifampin, Isoniazid, and Pyrazinamide
- Sitagliptin and metformin-Rifamycin
- Sitagliptin and metformin-Rifamycin Sodium
- Sitagliptin and metformin-Rifapentine
- Sitagliptin and metformin-Rifater
- Sitagliptin and metformin-Rifaximin