Rifapentine and Xarelto Starter Pack

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this interaction is not currently available.GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 may significantly decrease the plasma concentrations of rivaroxaban, which is a substrate of the isoenzyme. In a pharmacokinetic study, administration of a single 20 mg dose of rivaroxaban with the potent CYP450 3A4 inducer rifampin (titrated up to 600 mg once daily) resulted in approximately 22% and 50% decreases in mean rivaroxaban peak plasma concentration (Cmax) and system exposure (AUC), respectively, with parallel decreases in its pharmacodynamic effects. MANAGEMENT: Concomitant use of rivaroxaban with potent CYP450 3A4 inducers should generally be avoided. References Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink." Cerner Multum, Inc. "Australian Product Information." O 0 Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0 "Product Information. Xarelto (rivaroxaban)." Bayer Inc, Toronto, IA. View all 4 references

GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 may significantly decrease the plasma concentrations of rivaroxaban, which is a substrate of the isoenzyme. In a pharmacokinetic study, administration of a single 20 mg dose of rivaroxaban with the potent CYP450 3A4 inducer rifampin (titrated up to 600 mg once daily) resulted in approximately 22% and 50% decreases in mean rivaroxaban peak plasma concentration (Cmax) and system exposure (AUC), respectively, with parallel decreases in its pharmacodynamic effects.

MANAGEMENT: Concomitant use of rivaroxaban with potent CYP450 3A4 inducers should generally be avoided.

Rifapentine

Generic Name: rifapentine

Brand name: Priftin

Synonyms: n.a.

What is Rifapentine?

Xarelto Starter Pack

Generic Name: rivaroxaban

Brand name: Xarelto, Xarelto Starter Pack

Synonyms: Xarelto

What is Xarelto Starter Pack?