Rifapentine and Zofran (Ondansetron Oral Solution)
Determining the interaction of Rifapentine and Zofran (Ondansetron Oral Solution) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using rifapentine together with ondansetron may decrease the effects of ondansetron. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Concomitant use of rifamycin derivatives with ondansetron may result in a reduced antiemetic effect, particularly after the oral administration of ondansetron. The proposed mechanism is induction of the CYP450 3A4/1A2 mediated metabolism of ondansetron.
MANAGEMENT: Patients should be monitored for reduced antiemetic effects and the ondansetron dose adjusted as necessary.
- Villikka K, Kivisto KT, Neuvonen PJ "The effect of rifampin on the pharmacokinetics of oral and intravenous ondansetron." Clin Pharmacol Ther 65 (1999): 377-81
Generic Name: ondansetron
Brand name: Zofran, Zofran ODT, Zuplenz
Synonyms: Zofran
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Rifapentine-Zofran (Ondansetron Tablets)
- Rifapentine-Zofran injection
- Rifapentine-Zofran ODT
- Rifapentine-Zofran ODT Oral, Oromucosal
- Rifapentine-Zofran Oral, Oromucosal
- Rifapentine-Zohydro ER
- Zofran (Ondansetron Oral Solution)-Rifater
- Zofran (Ondansetron Oral Solution)-Rifaximin
- Zofran (Ondansetron Oral Solution)-Rilonacept
- Zofran (Ondansetron Oral Solution)-Rilonacept Subcutaneous
- Zofran (Ondansetron Oral Solution)-Rilpivirine
- Zofran (Ondansetron Oral Solution)-Rilpivirine Hydrochloride