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Rifater and Xanax

Determining the interaction of Rifater and Xanax and the possibility of their joint administration.

Check result:

Rifater <> Xanax

Relevance: 08.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using isoniazid together with rifAMPin can cause serious side effects that may affect your liver. Call your doctor immediately if you experience a fever, chills, joint pain or swelling, excessive tiredness or weakness, unusual bleeding or bruising, skin rash or itching, loss of appetite, nausea, vomiting, or yellowing of the skin or the whites of your eyes. If your doctor does prescribe these medications together, you may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR CLOSELY: The risk of hepatotoxicity is greater when rifampin and isoniazid are given concomitantly than when either drug is given alone. Rifampin appears to alter the metabolism of isoniazid and increase the amount of toxic metabolites. Theoretically, a similar reaction may occur with rifabutin and isoniazid. Patients who are elderly, have hepatic impairment, are slow acetylators of isoniazid, drink alcohol daily, are female, or are taking other strong CYP450-inducing agents may be at greater risk of hepatotoxicity.

MANAGEMENT: Close monthly monitoring for clinical or laboratory evidence of altered hepatic function is recommended. Patients should be advised to promptly report early symptoms of hepatitis such as fatigue, weakness, malaise, anorexia, nausea, or vomiting. Discontinuation of either or both drugs may be necessary.

References

Askgaard DS, Wilcke T, Dossing M "Hepatotoxicity caused by the combined action of isoniazid and rifampicin." Thorax 50 (1995): 213-4
Kumar A, Misra PK, Mehotra R, et al "Hepatotoxicity of rifampin and isoniazid." Am Rev Respir Dis 143 (1991): 1350-2
Abadie-Kemmerly S, Pankey GA, Dalvisio JR "Failure of ketoconazole treatment of blastomyces dermatidis due to interaction of isoniazid and rifampin." Ann Intern Med 109 (1988): 844-5
"Product Information. INH (isoniazid)." Ciba Pharmaceuticals, Summit, NJ.
"Product Information. Mycobutin (rifabutin)." Pharmacia and Upjohn, Kalamazoo, MI.
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0
Sarma G, Immanuel C, Kailasam S, Narayana AS, Venkatesan P "Rifampin-induced release of hydrazine from isoniazid." Am Rev Respir Dis 133 (1986): 1072-5
Steele MA, Burk RF, Des Prez RM "Toxic hepatitis with isoniazid and rifampin." Chest 99 (1991): 465-71
O'Brien RJ, Long MW, Cross FS, et al "Hepatotoxicity from isoniazid and rifampin among children treated for tuberculosis." Pediatrics 72 (1983): 491-9
Yamamoto T, Suou T, Hirayama C "Elevated serum aminotransferase induced by isoniazid in relation to isoniazid acetylator phenotype." Hepatology 6 (1986): 295-8
Acocella G, Bonollo L, Garimoldi M, et al "Kinetics of rifampicin and isoniazid administered alone and in combination to normal subjects and patients with liver disease." Gut 13 (1972): 47-53
"Product Information. Rifadin (rifampin)." Hoechst Marion-Roussel Inc, Kansas City, MO.
Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."

Rifater

Generic Name: isoniazid / pyrazinamide / rifampin

Brand name: Rifater

Synonyms: n.a.

What is Rifater?

Xanax

Generic Name: alprazolam

Brand name: Niravam, Xanax, Xanax XR, Alprazolam Intensol

Synonyms: n.a.

What is Xanax?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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