Rimactane and Telaprevir

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using telaprevir together with rifAMPin is not recommended. Combining these medications may decrease the blood levels of telaprevir, which may reduce its effectiveness in treating hepatitis C. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Coadministration with rifampin may significantly decrease the plasma concentrations of the hepatitis C virus (HCV) NS3/4A protease inhibitor, telaprevir. The mechanism is rifampin induction of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of telaprevir. In 16 study subjects, administration of a single 750 mg dose of telaprevir during treatment with rifampin 600 mg daily for 7 days reduced the telaprevir peak plasma concentration (Cmax) and systemic exposure (AUC) by an average of 86% and 92%, respectively, compared to administration alone.

MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic drug levels, concomitant use of telaprevir with rifampin is considered contraindicated.

Rimactane

Generic Name: rifampin

Brand name: Rifadin, Rifadin IV, Rimactane

Synonyms: n.a.

What is Rimactane?

Telaprevir

Generic Name: telaprevir

Brand name: Incivek

Synonyms: Telaprevir (Oral)

What is Telaprevir?