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Rimactane and Vasotec

Determining the interaction of Rimactane and Vasotec and the possibility of their joint administration.

Check result:
Rimactane <> Vasotec
Relevance: 06.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Rifampin may decrease the antihypertensive effects of enalapril and imidapril. The mechanism may involve decreased plasma concentrations of the active metabolites. The clinical significance is unknown. Management consists of monitoring blood pressure during therapy and increasing the anithypertensive dosage as needed and appropriate.

References
  • Kandiah D, Penny WJ, Fraser AG, Lewis MJ "A possible drug interaction between rifampicin and enalapril." Eur J Clin Pharmacol 35 (1988): 431-2
Rimactane

Generic Name: rifampin

Brand name: Rifadin, Rifadin IV, Rimactane

Synonyms: n.a.

Vasotec

Generic Name: enalapril

Brand name: Vasotec, Epaned

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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