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Rimactane and Verelan PM

Determining the interaction of Rimactane and Verelan PM and the possibility of their joint administration.

Check result:

Rimactane <> Verelan PM

Relevance: 06.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using rifAMPin together with verapamil may decrease the effects of verapamil. Contact your doctor if your condition changes or if you experience chest pain , increased blood pressure or difficulty breathing. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Rifampin may decrease the bioavailability, plasma levels, and pharmacological effects of verapamil. The mechanism is induction of CYP450 3A4 hepatic metabolism by rifampin. One study reported induction of verapamil metabolism continuing at least eight days after the discontinuation of rifampin. Rifabutin is also an enzyme inducer and a similar interaction is expected.

MANAGEMENT: Patients should be closely monitored for clinical efficacy of verapamil during coadministration, and conversely, for excessive calcium channel blockade when the rifamycin is discontinued. Alternative medications may be considered. Patients should be advised to notify their physician if they experience a worsening of their symptoms (e.g., angina, arrhythmia).

References

McTavish D, Sorkin EM "Verapamil: an updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension." Drugs 38 (1989): 19-76
Barbarash RA "Verapamil-rifampin interaction." Drug Intell Clin Pharm 19 (1985): 559-60
Tada Y, Tsuda Y, Otsuka T, et al "Case report: nifedipine-rifampicin interaction attenuates the effect on blood pressure in a patient with essential hypertension." Am J Med Sci 303 (1992): 25-7
Fromm MF, Busse D, Kroemer HK, Eichelbaum M "Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin." Hepatology 24 (1996): 796-801
Borcherding SM, Baciewicz AM, Self TH "Update on rifampin drug interactions." Arch Intern Med 152 (1992): 711-6
Venkatesan K "Pharmacokinetic drug interactions with rifampicin." Clin Pharmacokinet 22 (1992): 47-65
Barbarash RA, Bauman JL, Fischer JH, et al "Near-total reduction in verapamil bioavailability by rifampin: electrocardiographic correlates." Chest 94 (1988): 954-9
Strayhorn VA, Baciewicz AM, Self TH "Update on rifampin drug interactions, III." Arch Intern Med 157 (1997): 2453-8

Rimactane

Generic Name: rifampin

Brand name: Rifadin, Rifadin IV, Rimactane

Synonyms: n.a.

What is Rimactane?

Verelan PM

Generic Name: verapamil

Brand name: Verelan PM, Calan, Calan SR, Isoptin SR, Verelan, Isoptin, Isoptin IV, Covera-HS

Synonyms: n.a.

What is Verelan PM?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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