Riociguat and Sodium picosulfate, magnesium, and citric acid
Determining the interaction of Riociguat and Sodium picosulfate, magnesium, and citric acid and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Taking the riociguat and magnesium oxide doses too close together may interfere with the absorption of riociguat and reduce its effectiveness. To prevent or minimize the interaction, avoid taking magnesium oxide or other antacid-containing medications within one hour of taking riociguat. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: Concurrent administration of riociguat with antacids may reduce its gastrointestinal absorption. Riociguat exhibits pH-dependent solubility, with increased solubility at lower pH. According to the product labeling, administration of riociguat with an antacid containing aluminum hydroxide and magnesium hydroxide resulted in decreases of riociguat peak plasma concentration (Cmax) and systemic exposure (AUC) by approximately 50% and 30%, respectively. The Cmax and AUC of the active metabolite, M1, which has 1/3 to 1/10 the pharmacologic activity of riociguat, were similarly reduced.
MANAGEMENT: Antacids should not be taken within 1 hour of riociguat administration.
- "Product Information. Adempas (riociguat)." Bayer Pharmaceutical Inc, West Haven, CT.
Generic Name: citric acid / magnesium oxide / sodium picosulfate
Brand name: Clenpiq, Prepopik
Synonyms: Citric acid, magnesium oxide, and sodium picosulfate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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