Risedronate and Velphoro

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Sucroferric oxyhydroxide and risedronate should not be taken orally at the same time. Products that contain iron such as sucroferric oxyhydroxide may interfere with the absorption of risedronate and reduce its effectiveness. To prevent or minimize the interaction, you should take risedronate at least one to two hours before sucroferric oxyhydroxide. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSING INTERVAL: Coadministration with sucroferric oxyhydroxide may reduce the oral bioavailability of bisphosphonates. The proposed mechanism is chelation of bisphosphonates to the ferric ion component of sucroferric oxyhydroxide, forming an insoluble complex that is poorly absorbed from the gastrointestinal tract. According to the product labeling for sucroferric oxyhydroxide, an in vitro interaction with alendronate was observed when studied in aqueous solutions that mimic the physico-chemical conditions of the gastrointestinal tract.

MANAGEMENT: Alendronate should be administered at least 1 hour before sucroferric oxyhydroxide. No dosing recommendations are available for use with other bisphosphonates. Patients may follow the manufacturers' suggestion provided in the individual bisphosphonate label regarding use with mineral supplements and other polyvalent cation-containing products (i.e., administer sucroferric oxyhydroxide at least 30 minutes after risedronate, 1 hour after ibandronate, and at least 2 hours before or 2 hours after clodronate, etidronate, or tiludronate).

Risedronate

Generic Name: risedronate

Brand name: Actonel, Atelvia

Synonyms: n.a.

What is Risedronate?

Velphoro

Generic Name: sucroferric oxyhydroxide

Brand name: Velphoro

Synonyms: n.a.

What is Velphoro?