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Risedronate Sodium and Zinc Gluconate Capsules and Tablets

Determining the interaction of Risedronate Sodium and Zinc Gluconate Capsules and Tablets and the possibility of their joint administration.

Check result:
Risedronate Sodium <> Zinc Gluconate Capsules and Tablets
Relevance: 12.10.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Risedronate and zinc gluconate should not be taken orally at the same time. Products that contain magnesium, aluminum, calcium, iron, and/or other minerals may interfere with the absorption of risedronate into the bloodstream and reduce its effectiveness. You should take zinc gluconate at least 30 minutes after the risedronate dose. Talk to a healthcare professional if you are not sure whether a product contains something that could potentially interact with your medication or if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: Products containing aluminum, calcium, magnesium and other polyvalent cations such as antacids or vitamin with mineral supplements are likely to interfere with the gastrointestinal absorption of oral bisphosphonates. For example, the bioavailability of tiludronate has been shown to decrease 80% during simultaneous administration with calcium, and 60% when aluminum- or magnesium-containing antacids were administered one hour before tiludronate.

MANAGEMENT: Antacids or other oral medications containing aluminum, calcium, magnesium and other polyvalent cations should be administered at least 30 minutes after the bisphosphonate dose.

References
  • Darcy PF "Nutrient-drug interactions." Adverse Drug React Toxicol Rev 14 (1995): 233-54
  • "Product Information. Boniva (ibandronate)." Roche Laboratories, Nutley, NJ.
  • "Product Information. Skelid (tilundronate)." Sanofi Winthrop Pharmaceuticals, New York, NY.
  • "Product Information. Bonefos (clodronate)." Rhone-Poulenc Rorer Canada Inc, Laval, QC.
  • "Product Information. Actonel (risedronate)." Procter and Gamble Pharmaceuticals, Cincinnati, OH.
  • "Product Information. Fosamax (alendronate)." Merck & Co, Inc, West Point, PA.
Risedronate Sodium

Generic Name: risedronate

Brand name: Actonel, Atelvia

Synonyms: Risedronate

What is Risedronate Sodium?
Zinc Gluconate Capsules and Tablets

Generic Name: zinc gluconate

Brand name: Orazinc, Orazinc 110

Synonyms: Zinc gluconate, Zinc Gluconate

What is Zinc Gluconate Capsules and Tablets?
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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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