Ritonavir Tablets and Vorapaxar Sulfate
Determining the interaction of Ritonavir Tablets and Vorapaxar Sulfate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ritonavir may significantly increase the blood levels and effects of vorapaxar. Combining these medications may increase your risk of bleeding complications. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. You should seek immediate medical attention if you experience any unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with potent inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of vorapaxar, which is a substrate of the isoenzyme. When vorapaxar was coadministered with ketoconazole 400 mg, mean vorapaxar peak plasma concentration (Cmax) and systemic exposure (AUC) increased by nearly 2-fold.
MANAGEMENT: Concomitant use of vorapaxar with potent CYP450 3A4 inhibitors should generally be avoided.
- "Product Information. Zontivity (vorapaxar)." Merck & Company Inc, Whitehouse Station, NJ.
Generic Name: ritonavir
Brand name: Norvir, Norvir Soft Gelatin
Synonyms: Ritonavir
Generic Name: vorapaxar
Brand name: Zontivity
Synonyms: Vorapaxar
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Ritonavir Tablets-Voraxaze
- Ritonavir Tablets-Voriconazole
- Ritonavir Tablets-Voriconazole Injection
- Ritonavir Tablets-Voriconazole Oral, Intravenous
- Ritonavir Tablets-Voriconazole oral/injection
- Ritonavir Tablets-Voriconazole Suspension
- Vorapaxar Sulfate-Rituxan
- Vorapaxar Sulfate-Rituxan Hycela
- Vorapaxar Sulfate-Rituximab
- Vorapaxar Sulfate-Rituximab and Hyaluronidase
- Vorapaxar Sulfate-Rituximab and hyaluronidase human, recombinant Subcutaneous
- Vorapaxar Sulfate-Rituximab Intravenous