Ritonavir Tablets and Zyrtec

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using cetirizine together with ritonavir may increase the effects of cetirizine. Cetirizine effects may be increased during administration with ritonavir, particularly in the elderly and or if you have kidney impairment. Contact your doctor if you experience drowsiness and you should avoid activities requiring mental alertness until you know how these medications will affect you. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with ritonavir may increase the plasma concentrations of cetirizine. The exact mechanism is unknown but may involve ritonavir inhibition of the renal excretion of cetirizine. In 16 healthy volunteers, pretreatment with ritonavir (300 mg twice a day titrated to 600 mg twice a day, days 1 to 20) increased the steady-state area under the plasma concentration-time curve (AUC) and elimination half-life of cetirizine (10 mg orally once a day, days 15 to 20) by 42% and 53%, respectively, compared to administration of cetirizine alone. The apparent total body clearance of cetirizine was reduced by 29% with ritonavir. No serious drug-related adverse effects were reported in the study. Cetirizine did not significantly affect the pharmacokinetics of ritonavir.

MANAGEMENT: Pharmacologic effects of cetirizine may be increased during coadministration with ritonavir, particularly in the elderly and patients with renal impairment. Patients may experience increased somnolence and should be counseled to avoid activities requiring mental alertness until they know how these agents affect them. The same precaution may be applicable during therapy with levocetirizine, although clinical data are lacking.

Ritonavir Tablets

Generic Name: ritonavir

Brand name: Norvir, Norvir Soft Gelatin

Synonyms: Ritonavir

What is Ritonavir Tablets?

Zyrtec

Generic Name: cetirizine

Brand name: All Day Allergy, All Day Allergy Children's, GoodSense All Day Allergy, Indoor/Outdoor Allergy Relief, Zyrtec, Zyrtec

Synonyms: n.a.

What is Zyrtec?