Rolapitant Intravenous and Tranylcypromine Sulfate

• Generic Name: rolapitant
• Dosage Forms: n.a.
• Other Brand Names: Varubi

Rolapitant injection is used together with other medicines (eg, dexamethasone) to prevent delayed nausea and vomiting caused by cancer medicines (chemotherapy). Rolapitant is a substance P/neurokinin 1 (NK1) receptor antagonist that works by blocking the signals to the brain that cause nausea and vomiting.

Rolapitant is given only by or under the direct supervision of your doctor.

• Generic Name: tranylcypromine
• Dosage Forms: n.a.
• Other Brand Names: Parnate

Treatment of major depressive disorder without melancholia.

Efficacy in major depressive disorder with melancholia (endogenous features) not established.

MAO inhibitors appear particularly effective in treatment of major depressive disorder with atypical features, although other antidepressants (e.g., SSRIs) may initially be used because of their more favorable adverse effect profile.

Because of potential for serious adverse effects and necessity of dietary restrictions, MAO inhibitors (e.g., phenelzine, tranylcypromine) generally are not used as initial therapy for major depressive disorder, but are reserved for carefully selected patients who can be closely supervised and who have depression refractory to other antidepressants (e.g., SSRIs, SNRIs, TCAs) or in whom other therapies are contraindicated.