Ropivacaine Injection and Ticlopidine Hydrochloride

• Generic Name: ropivacaine
• Dosage Forms: n.a.
• Other Brand Names: Naropin, Naropin Polyamp, Naropin SDV, Naropin Novaplus

Ropivacaine is a local anesthetic given by injection to cause loss of feeling before and during surgery or labor and delivery. It does not cause loss of consciousness.

Ropivacaine is given only by or under the immediate supervision of a medical doctor, or by a specially trained nurse, in the doctor's office or in a hospital.

• Generic Name: ticlopidine
• Dosage Forms: n.a.
• Other Brand Names: Ticlid

Used to reduce the risk of fatal or nonfatal thrombotic stroke in patients who have had either a previous completed thrombotic stroke or stroke precursors (e.g., TIA, transient monocular or partial blindness [amaurosis fugax], reversible ischemic neurologic deficit, minor stroke).

Because of potentially life-threatening adverse effects (see Boxed Warning), reserve for patients who are unable to tolerate or have hypersensitivity to aspirin or those who have failed to respond to aspirin therapy where indicated to prevent stroke.

The American College of Chest Physicians (ACCP) states that use of ticlopidine for secondary prevention of stroke has become severely limited because of the risk of serious adverse effects and the availability of safer antiplatelet agents.

Used as an adjunct to aspirin therapy to reduce the incidence of subacute stent thrombosis after PCI with successful coronary artery stent placement.

Ticlopidine for this use largely has been replaced by other antiplatelet agents. ACCP and other experts currently recommend dual-drug antiplatelet therapy with other P2Y12-receptor antagonists (e.g., clopidogrel, prasugrel, ticagrelor) and aspirin in patients undergoing PCI with stent placement.