About us Contacts Drug interactions: 390 212
Drug search by name

Rosuvastatin and Tavalisse

Determining the interaction of Rosuvastatin and Tavalisse and the possibility of their joint administration.

Check result:
Rosuvastatin <> Tavalisse
Relevance: 13.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Fostamatinib may increase the blood levels and effects of rosuvastatin. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with fostamatinib may increase the plasma concentrations of rosuvastatin. The proposed mechanism is decreased clearance due to inhibition of the breast cancer resistance protein (BCRP) transporter by fostamatinib. According to the product labeling, administration of a single 20 mg dose of rosuvastatin with fostamatinib 100 mg twice daily increased rosuvastatin peak plasma concentration (Cmax) and systemic exposure (AUC) by 88% and 95%, respectively.

MANAGEMENT: Caution is advised when fostamatinib is used concurrently with rosuvastatin or other drugs that are known substrates of BCRP, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever fostamatinib is added to or withdrawn from therapy.

References
  • "Product Information. Tavalisse (fostamatinib)." Rigel Pharmaceuticals, South San Francisco, CA.
Rosuvastatin

Generic Name: rosuvastatin

Brand name: Crestor, Ezallor Sprinkle

Synonyms: n.a.

Tavalisse

Generic Name: fostamatinib

Brand name: Tavalisse

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction