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Roxanol and Verapamil Sustained-Release Capsules

Determining the interaction of Roxanol and Verapamil Sustained-Release Capsules and the possibility of their joint administration.

Check result:
Roxanol <> Verapamil Sustained-Release Capsules
Relevance: 05.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

One study of polysubstance abusers has suggested that verapamil may attenuate the euphoragenic effects of morphine and potentiate the analgesic effects. The clinical implications of this interaction for patients with pain are unknown.

References
  • Vaupel DB, Lange WR, London ED "Effects of verapamil on morphine-induced euphoria, analgesia and respiratory depression in humans." J Pharmacol Exp Ther 267 (1993): 1386-94
Roxanol

Generic Name: morphine

Brand name: Roxanol, Arymo ER, Kadian, MorphaBond ER, Avinza, MS Contin, Duramorph PF, Infumorph, Mitigo, RMS

Synonyms: n.a.

Verapamil Sustained-Release Capsules

Generic Name: verapamil

Brand name: Calan, Isoptin SR, Verelan, Isoptin, Calan SR, Isoptin IV, Covera-HS, Verelan PM

Synonyms: Verapamil

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle