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Rubex and Vincasar PFS

Determining the interaction of Rubex and Vincasar PFS and the possibility of their joint administration.

Check result:

Rubex <> Vincasar PFS

Relevance: 18.06.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Concurrent administration of vincristine and doxorubicin may lead to an earlier onset and/or an increased severity of side effects. The mechanism is the inhibition of the metabolism of both drugs by a hepatic cytochrome P-450 isoenzyme in the CYP 3A subfamily. The clinical significance of this interaction has not been established. If vincristine and doxorubicin are used concomitantly, caution and close observation are advised.

References

Zhou-Pan XR, Seree E, Zhou XJ, et al "Involvement of human liver cytochrome P450 3A in vinblastine metabolism: drug interactions." Cancer Res 53 (1993): 5121-6
"Product Information. Oncovin (vincristine)." Lilly, Eli and Company, Indianapolis, IN.

Rubex

Generic Name: doxorubicin

Brand name: Adriamycin, Adriamycin RDF, Rubex, Adriamycin PFS

Synonyms: Doxorubicin, DOXOrubicin (Conventional)

What is Rubex?

Vincasar PFS

Generic Name: vincristine

Brand name: Oncovin, Vincasar PFS

Synonyms: n.a.

What is Vincasar PFS?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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