Rubraca and Theraflu Nighttime Severe Cold
Determining the interaction of Rubraca and Theraflu Nighttime Severe Cold and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Rucaparib may increase the blood levels and effects of acetaminophen. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with rucaparib may increase the plasma concentrations and the risk of adverse effects of drugs that are substrates of CYP450 1A2. The proposed mechanism is decreased clearance due to rucaparib-mediated inhibition of CYP450 1A2.
MANAGEMENT: Caution is advised if rucaparib is used concomitantly with drugs that are substrates of CYP450 1A2, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring should be considered whenever rucaparib is added to or withdrawn from therapy with these drugs. Patients should be monitored for the development of adverse effects.
- EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/regulation/document_listing/document_listing_000366.jsp&mid=WC0b01ac058067c852" ([2013 - ]):
Generic Name: acetaminophen / pheniramine / phenylephrine
Brand name: Flu & Severe Cold Night Time, Theraflu Flu & Sore Throat, Theraflu Nighttime Severe Cold, Theraflu Sinus & Cold, Theraflu Cold & Sore Throat, Theraflu Cold and Sore Throat, Theraflu Flu and Sore Throat
Synonyms: Theraflu Flu & Sore Throat
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Rubraca-Theraflu Nighttime Severe Cough and Cold
- Rubraca-Theraflu PowerPods (Acetaminophen, Dextromethorphan, and Phenylephrine Pods)
- Rubraca-Theraflu PowerPods (Acetaminophen, Diphenhydramine, and Phenylephrine Pods)
- Rubraca-Theraflu Severe Cold & Congestion
- Rubraca-Theraflu Severe Cold & Congestion Non-Drowsy
- Rubraca-Theraflu Severe Cold & Cough Nighttime
- Theraflu Nighttime Severe Cold-Rubramin PC
- Theraflu Nighttime Severe Cold-Rucaparib
- Theraflu Nighttime Severe Cold-Rucaparib Camsylate
- Theraflu Nighttime Severe Cold-Ruconest
- Theraflu Nighttime Severe Cold-Rufinamide
- Theraflu Nighttime Severe Cold-Rufinamide Oral Suspension