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Rubraca and Tylenol Warming Cough & Sore Throat Nightime

Determining the interaction of Rubraca and Tylenol Warming Cough & Sore Throat Nightime and the possibility of their joint administration.

Check result:

Rubraca <> Tylenol Warming Cough & Sore Throat Nightime

Relevance: 03.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Rucaparib may increase the blood levels and effects of acetaminophen. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with rucaparib may increase the plasma concentrations and the risk of adverse effects of drugs that are substrates of CYP450 1A2. The proposed mechanism is decreased clearance due to rucaparib-mediated inhibition of CYP450 1A2.

MANAGEMENT: Caution is advised if rucaparib is used concomitantly with drugs that are substrates of CYP450 1A2, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring should be considered whenever rucaparib is added to or withdrawn from therapy with these drugs. Patients should be monitored for the development of adverse effects.

References

EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/regulation/document_listing/document_listing_000366.jsp&mid=WC0b01ac058067c852" ([2013 - ]):

Rubraca

Generic Name: rucaparib

Brand name: Rubraca

Synonyms: n.a.

What is Rubraca?

Tylenol Warming Cough & Sore Throat Nightime

Generic Name: acetaminophen / dextromethorphan / doxylamine

Brand name: All-Nite, Contac Cold+Flu Cooling Night, Coricidin HBP Nighttime Multi-Symptom Cold, Night Time Cold/Flu, Nyquil Cold & Flu, Robitussin Peak Cold Nighttime Cold + Flu, Tylenol Cold & Cough Nighttime Cool Burst, Tylenol Warming Cough & Sore Throat Nightime, Tylenol Cough & Sore Throat Nightime, Tylenol Cough & Sore Throat Night Time, NyQuil Cold/Flu Relief Cherry, NyQuil Cold/Flu Relief, Nite Time Cold & Flu, Cough & Sore Throat Nighttime, Delsym Cough-Cold Nighttime, Sunmark Nite Time Cold and Flu, Delsym Nighttime Cough & Cold, Multi-Symptom Nighttime Cold & Flu Relief, Nyquil Cold & Flu Nighttime, NyQuil Nature Fusion Cold & Flu Nighttime, Clear Cough PM Multi-Symptom, Tylenol Cough/Sore Throat

Synonyms: Acetaminophen, dextromethorphan, and doxylamine

What is Tylenol Warming Cough & Sore Throat Nightime?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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