Rucaparib and Sudafed PSE

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Rucaparib may increase the blood levels and effects of naproxen. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with rucaparib may increase the plasma concentrations and the risk of adverse effects of drugs that are substrates of CYP450 1A2. The proposed mechanism is decreased clearance due to rucaparib-mediated inhibition of CYP450 1A2.

MANAGEMENT: Caution is advised if rucaparib is used concomitantly with drugs that are substrates of CYP450 1A2, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring should be considered whenever rucaparib is added to or withdrawn from therapy with these drugs. Patients should be monitored for the development of adverse effects.

Rucaparib

Generic Name: rucaparib

Brand name: Rubraca

Synonyms: n.a.

What is Rucaparib?

Sudafed PSE

Generic Name: naproxen / pseudoephedrine

Brand name: Aleve Cold and Sinus, Aleve Sinus & Headache, Aleve-D Sinus & Cold, Sudafed PSE, Aleve-D Cold and Sinus, Sudafed Sinus & Pain 12 Hour, Sinus & Cold-D, Sudafed Sinus 12 Hour Pressure + Pain, Aleve-D Sinus & Headache, Sudafed 12 Hour Pressure + Pain

Synonyms: Naproxen and pseudoephedrine

What is Sudafed PSE?