Rucaparib Camsylate and Zetonna

• Generic Name: rucaparib
• Dosage Forms: n.a.
• Other Brand Names: Rubraca

Single-agent therapy for the treatment of deleterious germline and/or somatic BRCA-mutated (as detected by an FDA-approved companion diagnostic test [FoundationFocus CDx BRCA]) advanced ovarian cancer previously treated with ≥2 chemotherapy regimens (designated an orphan drug by FDA for this use). Subgroup analysis suggests overall response rate is higher in patients with platinum-sensitive disease than in those with platinum-resistant disease (66 versus 25%); no responses observed in a limited number of patients with platinum-refractory disease.

Accelerated approval based on overall response rate and duration of response. Continued approval may be contingent on verification and description of clinical benefit in confirmatory studies.

Women with mutations that result in defective BRCA genes are more likely to develop ovarian cancer. Approximately 10–15% of all cases of ovarian cancer appear to be associated with these hereditary BRCA mutations.

• Generic Name: ciclesonide nasal
• Dosage Forms: nasal aerosol, metered
• Other Brand Names: Omnaris, Zetonna

Zetonna (ciclesonide) is a man-made steroid that prevents the release of substances in the body that cause inflammation.

Zetonna nasal spray is used to treat nasal symptoms (congestion, sneezing, runny nose) caused by seasonal allergies in adults and children as young as 6 years old. Zetonna is also used to treat nasal symptoms caused by year-round allergies in adults and children who are at least 12 years old.

Zetonna may also be used for purposes not listed in this medication guide.