Rybix ODT and Zometa

• Generic Name: tramadol
• Dosage Forms: tablet, orally disintegrating
• Other Brand Names: ConZip, Ultram, Ultram ER, Rybix ODT, Ryzolt

Tramadol is used to relieve moderate to moderately severe pain, including pain after surgery. The extended-release capsules or tablets are used for chronic ongoing pain.

Tramadol belongs to the group of medicines called opioid analgesics. It acts in the central nervous system (CNS) to relieve pain.

When tramadol is used for a long time, it may become habit-forming, causing mental or physical dependence. However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve their pain. Mental dependence (addiction) is not likely to occur when narcotics are used for this purpose. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely.

This medicine is available only under a restricted distribution program called the Opioid Analgesic REMS (Risk Evaluation and Mitigation Strategy) program.

• Generic Name: zoledronic acid
• Dosage Forms: injection, solution, concentrate
• Other Brand Names: Reclast, Zometa, Aclasta, Zometa Concentrate

Zometa (zoledronic acid) (sometimes called zoledronate) is a bisphosphonate medicine that alters bone formation and breakdown in the body. This can slow bone loss and may help prevent bone fractures.

Zometa is used to treat high blood levels of calcium caused by cancer (also called hypercalcemia of malignancy). Zometa also treats multiple myeloma (a type of bone marrow cancer) or bone cancer that has spread from elsewhere in the body.

The Reclast brand of zoledronic acid is used in men and women to treat or prevent osteoporosis caused by menopause or by taking steroids. Reclast is also used to increase bone mass in men who have osteoporosis, and to treat Paget's disease of bone in men and women.

You should not use Reclast and Zometa at the same time.