Rydapt and Seconal Sodium

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Secobarbital may reduce the blood levels of midostaurin in some patients, which may make the medication less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of midostaurin and its active metabolites, which are all substrates of the isoenzyme. When a single 50 mg dose of midostaurin was administered to healthy volunteers on day 9 of treatment with the potent CYP450 3A4 inducer rifampin (600 mg daily for 14 days), midostaurin systemic exposure (AUC) decreased by 96% compared to administration with placebo. The AUC of the two active metabolites, CGP62221 and CGP52421, decreased by 92% and 59%, respectively. It is not known to what extent midostaurin may interact with weak and moderate CYP450 3A4 inducers.

MANAGEMENT: The potential for diminished pharmacologic effects of midostaurin should be considered during coadministration with CYP450 3A4 inducers. Alternative treatments may be required if an interaction is suspected.

Rydapt

Generic Name: midostaurin

Brand name: Rydapt

Synonyms: n.a.

What is Rydapt?

Seconal Sodium

Generic Name: secobarbital

Brand name: Seconal Sodium, Seconal

Synonyms: n.a.

What is Seconal Sodium?