Drug search by name

Sabril and Tegretol

Determining the interaction of Sabril and Tegretol and the possibility of their joint administration.

Check result:

Sabril <> Tegretol

Relevance: 25.11.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Coadministration of vigabatrin with carbamazepine may have no effect, or it may modestly increase or decrease the plasma concentrations of carbamazepine. The mechanism of interaction is unknown. Several studies have reported that carbamazepine levels were not significantly altered by the addition of vigabatrin. In contrast, in a study involving 59 patients receiving carbamazepine, following the addition of vigabatrin, 3 patients exhibited no change in carbamazepine levels, 34 experienced an increase in carbamazepine levels and 22 had a decrease in carbamazepine levels. In another study, 69% of patients exhibited an increase in carbamazepine levels of at least 10% with a mean increase of approximately 24%. In yet another study involving 15 patients with refractory partial epilepsy, the addition of vigabatrin (1500 to 4000 mg/day for at least 3 months) to existing carbamazepine monotherapy (800 to 1200 mg/day orally for 3 to 12 months) decreased the mean steady-state plasma trough concentration (Cmin) and plasma concentration-to-dose ratio of carbamazepine by 18% and 24%, respectively, compared to baseline. The mean carbamazepine plasma clearance increased by 35%. These changes are unlikely to be of therapeutic significance in most patients, and dose adjustments are not routinely required. Based on population pharmacokinetics, carbamazepine appears to have no effect on the plasma concentrations of vigabatrin.

References

"Product Information. Sabril (vigabatrin)." Lundbeck Inc, Deerfield, IL.
Tassinari CA, Michelucci R, Ambrosetto G, Salvi F "Double-blind study of vigabatrin in the treatment of drug-resistant epilepsy." Arch Neurol 44 (1987): 907-10
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Sanchez-Alcaraz A, Quintana MB, Lopez E, Rodriguez I, Llopis P "Effect of vigabatrin on the pharmacokinetics of carbamazepine." J Clin Pharm Ther 27 (2002): 427-30
Browne TR, Mattson RH, Penry JK, Smith DB, Treiman DM, Wilder BJ, Ben-Menachem E, Napoliello MJ, Sherry KM, Szabo GK "Vigabatrin for refractory complex partial seizures: multicenter single-blind study with long-term follow-up." Neurology 37 (1987): 184-9
Jedrzejczak J, Dlawichowska E, Owczarek K, Majkowski J "Effect of vigabatrin addition on carbamazepine blood serum levels in patients with epilepsy." Epilepsy Res 39 (2000): 115-20

Sabril

Generic Name: vigabatrin

Brand name: Sabril, Vigadrone

Synonyms: n.a.

What is Sabril?

Tegretol

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Tegretol?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions