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Safinamide Mesylate and Vitrakvi (Larotrectinib Oral Solution)

Determining the interaction of Safinamide Mesylate and Vitrakvi (Larotrectinib Oral Solution) and the possibility of their joint administration.

Check result:

Safinamide Mesylate <> Vitrakvi (Larotrectinib Oral Solution)

Relevance: 15.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this interaction is not currently available.MONITOR: Coadministration with safinamide may increase the plasma concentrations of drugs that are substrates of the breast cancer resistance protein (BCRP) transporter. The proposed mechanism is decreased clearance due to intestinal BCRP-inhibition by safinamide. MANAGEMENT: Caution is advised when safinamide is prescribed with drugs that are BCRP substrates, particularly those with a narrow therapeutic range such as methotrexate, topotecan, and irinotecan. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever safinamide is added to or withdrawn from therapy. References "Product Information. Xadago (safinamide)." US WorldMeds LLC, Louisville , KY.

Professional:

MONITOR: Coadministration with safinamide may increase the plasma concentrations of drugs that are substrates of the breast cancer resistance protein (BCRP) transporter. The proposed mechanism is decreased clearance due to intestinal BCRP-inhibition by safinamide.

MANAGEMENT: Caution is advised when safinamide is prescribed with drugs that are BCRP substrates, particularly those with a narrow therapeutic range such as methotrexate, topotecan, and irinotecan. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever safinamide is added to or withdrawn from therapy.

References

"Product Information. Xadago (safinamide)." US WorldMeds LLC, Louisville , KY.

Safinamide Mesylate

Generic Name: safinamide

Brand name: Xadago

Synonyms: Safinamide

What is Safinamide Mesylate?

Vitrakvi (Larotrectinib Oral Solution)

Generic Name: larotrectinib

Brand name: Vitrakvi

Synonyms: Vitrakvi

What is Vitrakvi (Larotrectinib Oral Solution)?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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