Drug search by name

Sandimmune and Seconal Sodium

Determining the interaction of Sandimmune and Seconal Sodium and the possibility of their joint administration.

Check result:

Sandimmune <> Seconal Sodium

Relevance: 15.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using secobarbital together with cycloSPORINE may decrease the effects of cycloSPORINE. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Barbiturates may decrease serum cyclosporine concentrations and efficacy. The mechanism is enhanced hepatic microsomal metabolism of cyclosporine. A case report has described this interaction for phenobarbital; however, the barbiturates are known enzyme inducers. Effects may not be apparent until 1 to 2 weeks after the barbiturate is added to the regimen or its dose is changed.

MANAGEMENT: Cyclosporine levels should be closely monitored during concomitant therapy and more frequently when a barbiturate is started or stopped. The dosage of cyclosporine should be adjusted to maintain therapeutic concentrations. Some experts suggest that this interaction could persist for a week or more following discontinuation of the barbiturate. Alternatively, a benzodiazepine may be used, if clinically appropriate.

References

Carstensen H, Jacobsen N, Dieperink H "Interaction between cyclosporin A and phenobarbitone." Br J Clin Pharmacol 21 (1986): 550-1
Yee GC, McGuire TR "Pharmacokinetic drug interactions with cyclosporin (Part I)." Clin Pharmacokinet 19 (1990): 319-32
Cerner Multum, Inc. "Australian Product Information." O 0
Wideman CA "Pharmacokinetic monitoring of cyclosporine." Transplant Proc 15(1/2) (1983): 3168-75
Burckart GJ, Venkataramanan R, Ptachcinski RJ "Usefulness of cyclosporin monitoring questioned." Clin Pharm 3 (1984): 243
Noguchi M, Kiuchi C, Akiyama H, et al "Interaction between cyclosporin A and anticonvulsants." Bone Marrow Transplant 9 (1992): 391
Kerr LE "Drug interactions with cyclosporine." Clin Pharm 3 (1984): 346,348
"Product Information. Neoral Soft Gelatin Capsules (cyclosporine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
"Product Information. Sandimmune (cyclosporine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cockburn IT, Krupp P "An appraisal of drug interactions with sandimmun." Transplant Proc 21 (1989): 3845-50

Sandimmune

Generic Name: cyclosporine

Brand name: Sandimmune, Gengraf, Neoral, Sandimmune

Synonyms: Sandimmune (Injection)

What is Sandimmune?

Seconal Sodium

Generic Name: secobarbital

Brand name: Seconal Sodium, Seconal

Synonyms: n.a.

What is Seconal Sodium?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions