Sandimmune (Cyclosporine Injection) and Stiripentol Capsules
Determining the interaction of Sandimmune (Cyclosporine Injection) and Stiripentol Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Stiripentol may increase the blood levels and effects of cycloSPORINE. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: The concomitant administration of stiripentol may increase plasma concentrations and toxic effects of certain hepatically metabolized drugs including ergot alkaloids, quinidine, immunosuppressants, and statins. The mechanism is inhibition of CYP450 3A4 metabolism by stiripentol. Clinical data have not been reported.
MANAGEMENT: The manufacturer recommends that concomitant use should be avoided, unless strictly necessary.
- EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid."
Generic Name: cyclosporine
Brand name: Sandimmune, Gengraf, Neoral, Sandimmune
Synonyms: Sandimmune (Injection), Sandimmune
Generic Name: stiripentol
Brand name: Diacomit
Synonyms: Stiripentol
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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