Sandimmune (Cyclosporine Soft Gelatin Capsules) and Tolazamide

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using cycloSPORINE together with TOLAZamide may increase the effects of cycloSPORINE. Contact your doctor if you experience nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, or headache. If your doctor prescribes these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Glipizide may decrease the metabolism of cyclosporine. Cyclosporine levels may be increased by as much as 150%. It is not known whether other sulfonylureas will exhibit a similar interaction, although limited data do exist for glyburide. The proposed mechanism is inhibition of CYP450 hepatic metabolism.

MANAGEMENT: If a sulfonylurea is added or discontinued in a patient stabilized on cyclosporine, serum cyclosporine levels should be closely monitored. Patients should be advised to notify their physician if they experience nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, or headache.

Sandimmune (Cyclosporine Soft Gelatin Capsules)

Generic Name: cyclosporine

Brand name: Sandimmune, Gengraf, Neoral, Sandimmune

Synonyms: Sandimmune (Injection), Sandimmune

What is Sandimmune (Cyclosporine Soft Gelatin Capsules)?

Tolazamide

Generic Name: tolazamide

Brand name: Tolinase

Synonyms: TOLAZamide

What is Tolazamide?