Sapropterin Powder for Oral Solution and Stalevo

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using sapropterin together with levodopa may alter the effects of levodopa. Contact your doctor if your condition changes or if you experience uncontrollable movements of the face, eyelids, mouth, tongue, neck, arms, hands, or legs, irritability, or unusual changes in mood or behavior. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration of sapropterin and levodopa has been associated with neurologic adverse effects. The mechanism of interaction has not been described. In a 10-year postmarketing safety surveillance program for a non-PKU indication using a particular formulation of sapropterin, three patients with underlying neurologic disorders experienced convulsions, exacerbation of convulsions, overstimulation, and irritability during coadministration with levodopa.

MANAGEMENT: Caution is advised if sapropterin is prescribed to patients receiving levodopa.

Sapropterin Powder for Oral Solution

Generic Name: sapropterin

Brand name: Kuvan

Synonyms: Sapropterin

What is Sapropterin Powder for Oral Solution?

Stalevo

Generic Name: carbidopa / entacapone / levodopa

Brand name: Stalevo, Stalevo 100, Stalevo 125, Stalevo 150, Stalevo 200, Stalevo 50, Stalevo 75

Synonyms: n.a.

What is Stalevo?