Saquinavir and Yosprala

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using saquinavir together with omeprazole may increase the effects of saquinavir. Contact your doctor if you experience fever, sore throat, and headache with a severe blistering, peeling, and red skin rash, increased urination or extreme thirst, easy bruising or bleeding, signs of a new infection, such as fever or chills, cough, or flu symptoms, or nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: The concomitant administration of some proton pump inhibitors with saquinavir, with or without ritonavir, may significantly increase exposure to saquinavir. When omeprazole 40 mg once daily and saquinavir/ritonavir 1000 mg/100 mg twice daily were administered to healthy subjects (n=18), the steady-state area under the concentration-time curve (AUC) and maximum plasma concentrations (Cmax) of saquinavir were increased by an average of 82 % (range, 37% to 234%) and 75 % (range, 31% to 234%), respectively, compared to saquinavir/ritonavir. Ritonavir concentrations were not changed significantly. The mechanism is unknown.

MANAGEMENT: Clinical and laboratory monitoring for saquinavir toxicity is recommended during concurrent use of a proton pump inhibitor. According to some authorities, a dose reduction for saquinavir may be considered.

Saquinavir

Generic Name: saquinavir

Brand name: Invirase, Fortovase

Synonyms: n.a.

What is Saquinavir?

Yosprala

Generic Name: aspirin / omeprazole

Brand name: Yosprala

Synonyms: n.a.

What is Yosprala?