Seconal Sodium and Sirturo

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Secobarbital may reduce the blood levels and effects of bedaquiline. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of bedaquiline, which is primarily metabolized by CYP450 3A4 to the major N-monodesmethyl metabolite, M2. Because M2 is 4- to 6-fold less active than the parent drug in terms of antimycobacterial potency, the interaction may diminish the therapeutic effect of bedaquiline. In healthy volunteers, administration of a single 300 mg dose of bedaquiline in combination with the potent CYP450 3A4 inducer rifampin (600 mg once daily for 21 days) reduced bedaquiline systemic exposure (AUC) by 52% compared to administration alone. No data are available for use with other, less potent CYP450 3A4 or P-gp inducers.

MANAGEMENT: Caution is advised when bedaquiline is used in combination with inducers of CYP450 3A4 due to the potential for reduced antimycobacterial effect.

Seconal Sodium

Generic Name: secobarbital

Brand name: Seconal Sodium, Seconal

Synonyms: n.a.

What is Seconal Sodium?

Sirturo

Generic Name: bedaquiline

Brand name: Sirturo

Synonyms: n.a.

What is Sirturo?