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Seconal Sodium and Symfi Lo

Determining the interaction of Seconal Sodium and Symfi Lo and the possibility of their joint administration.

Check result:

Seconal Sodium <> Symfi Lo

Relevance: 16.02.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Secobarbital may decrease the blood levels and effects of efavirenz. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of efavirenz, which is primarily metabolized by the isoenzyme.

MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, caution is advised if efavirenz is prescribed in combination with CYP450 3A4 inducers. Close clinical and laboratory monitoring of antiretroviral response is recommended. Alternative treatment that do not affect efavirenz metabolism should be considered whenever possible.

References

Marzolini C, Telenti A, Decosterd LA, Greub G, Biollaz J, Buclin T "Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients." Aids 15 (2001): 71-5
"Product Information. Sustiva (efavirenz)." DuPont Pharmaceuticals, Wilmington, DE.

Seconal Sodium

Generic Name: secobarbital

Brand name: Seconal Sodium, Seconal

Synonyms: n.a.

What is Seconal Sodium?

Symfi Lo

Generic Name: efavirenz / lamivudine / tenofovir

Brand name: Symfi, Symfi Lo

Synonyms: n.a.

What is Symfi Lo?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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