Segesterone acetate and ethinyl estradiol Vaginal and Tranylcypromine Sulfate

• Generic Name: ethinyl estradiol / segesterone
• Dosage Forms: n.a.
• Other Brand Names: Annovera

Segesterone acetate and ethinyl estradiol combination is used to prevent pregnancy. It is a flexible birth control vaginal system (in the shape of a ring) that contains two types of hormones, segesterone acetate and ethinyl estradiol. It works by stopping a woman's egg from fully developing each month. The egg can no longer accept a sperm and fertilization (pregnancy) is prevented.

No contraceptive method is 100 percent effective. Birth control methods such as having surgery to become sterile or not having sex are more effective than vaginal systems. Discuss your options for birth control with your doctor.

Segesterone acetate and ethinyl estradiol will not prevent HIV infection or other sexually transmitted diseases. It will not help as emergency contraception, such as after unprotected sexual contact.

Segesterone acetate and ethinyl estradiol is available only with your doctor's prescription.

• Generic Name: tranylcypromine
• Dosage Forms: n.a.
• Other Brand Names: Parnate

Treatment of major depressive disorder without melancholia.

Efficacy in major depressive disorder with melancholia (endogenous features) not established.

MAO inhibitors appear particularly effective in treatment of major depressive disorder with atypical features, although other antidepressants (e.g., SSRIs) may initially be used because of their more favorable adverse effect profile.

Because of potential for serious adverse effects and necessity of dietary restrictions, MAO inhibitors (e.g., phenelzine, tranylcypromine) generally are not used as initial therapy for major depressive disorder, but are reserved for carefully selected patients who can be closely supervised and who have depression refractory to other antidepressants (e.g., SSRIs, SNRIs, TCAs) or in whom other therapies are contraindicated.