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Seldane and Sotalol Intravenous

Determining the interaction of Seldane and Sotalol Intravenous and the possibility of their joint administration.

Check result:

Seldane <> Sotalol Intravenous

Relevance: 03.08.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Terfenadine is no longer on the market in the US. Do not take terfenadine with any other medication.

Professional:

GENERALLY AVOID: A single case report describes the occurrence of torsades de pointes due to the addition of terfenadine therapy to a patient stable on sotalol. The arrhythmia presented 7 days after terfenadine was started. The mechanism is unknown, but is thought to be related to cumulative effects of the drug combination on the QT interval. Other non-sedating antihistamines that can prolong the QT interval may interact similarly.

MANAGEMENT: Alternate antihistamine therapy, such as cetirizine, fexofenadine or loratadine is recommended.

References

Feroze H, Suri R, Silverman DI "Torsades de pointes from terfenadine and sotalol given in combination." Pacing Clin Electrophysiol 19 (1996): 1519-21

Seldane

Generic Name: terfenadine

Brand name: Seldane

Synonyms: n.a.

What is Seldane?

Sotalol Intravenous

Generic Name: sotalol

Brand name: Betapace, Sorine, Betapace AF, Sotalol Hydrochloride AF, Sotylize

Synonyms: Sotalol (Intravenous)

What is Sotalol Intravenous?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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