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Seldane and Vfend

Determining the interaction of Seldane and Vfend and the possibility of their joint administration.

Check result:

Seldane <> Vfend

Relevance: 03.08.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Terfenadine is no longer on the market in the US. Do not take terfenadine with any other medication.

Professional:

CONTRAINDICATED: Coadministration with azole antifungal agents may significantly increase the plasma concentrations of terfenadine. The mechanism is azole inhibition of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of terfenadine. High plasma levels of terfenadine have been associated with prolongation of the QT interval on the ECG; ventricular arrhythmias including ventricular tachycardia and torsade de pointes; cardiac arrest; and sudden death. Within the azole class, ketoconazole and itraconazole are considered the most potent inhibitors, while fluconazole is comparatively weak and generally causes clinically significant interactions with CYP450 3A4 substrates only at dosages of 200 mg/day or more. In six healthy volunteers, fluconazole (200 mg daily for 7 days) had no effect on the steady-state plasma concentrations of terfenadine (60 mg twice a day for 15 days) or the cardiac repolarization as measured by Holter QTc intervals. However, another study using fluconazole dosages of 400 and 800 mg/day demonstrated significant increases in the plasma levels of terfenadine.

MANAGEMENT: The use of terfenadine with most azole antifungal agents, including fluconazole at multiple doses of 400 mg or higher, is considered contraindicated. Loratadine, cetirizine, or fexofenadine may be safer alternatives during therapy with azole antifungal agents.

References

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Seldane

Generic Name: terfenadine

Brand name: Seldane

Synonyms: n.a.

What is Seldane?

Vfend

Generic Name: voriconazole

Brand name: Vfend, Vfend

Synonyms: Vfend Injection

What is Vfend?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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