Drug search by name

Selegiline and Tapentadol

Determining the interaction of Selegiline and Tapentadol and the possibility of their joint administration.

Check result:

Selegiline <> Tapentadol

Relevance: 20.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using tapentadol together with selegiline is not recommended. Combining these medications can increase the risk of seizures as well as cardiovascular side effects such as low or high blood pressure and irregular heart rhythm. In addition, these medications can cause a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, blurred vision, muscle spasm or stiffness, tremor, stomach cramp, nausea, vomiting, and diarrhea. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: Monoamine oxidase inhibitors (MAOIs) may potentiate the noradrenergic and serotonergic activities of tapentadol. The mechanism is an additive pharmacodynamic effect resulting from MAOI inhibition of norepinephrine and serotonin metabolism and tapentadol inhibition of their reuptake. Theoretically, coadministration may increase the risk of adverse cardiovascular effects such as hypotension, hypertension, and arrhythmias due to elevated norepinephrine levels. In addition, an increased risk of seizure may occur due to additive lowering of seizure threshold. The interaction may also cause serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A receptors. Symptoms of the serotonin syndrome may include mental status changes such as irritability, altered consciousness, confusion, hallucinations, and coma; autonomic dysfunction such as tachycardia, hyperthermia, diaphoresis, shivering, blood pressure lability, and mydriasis; neuromuscular abnormalities such as hyperreflexia, myoclonus, tremor, rigidity, and ataxia; and gastrointestinal symptoms such as abdominal cramping, nausea, vomiting, and diarrhea.

MANAGEMENT: The use of tapentadol in patients currently receiving or within 14 days of receiving a monoamine oxidase inhibitor (MAOI) is considered contraindicated.

References

De Vita VT, Hahn MA, Oliverio VT "Monoamine oxidase inhibition by a new carcinostatic agent, n-isopropyl-a-(2-methylhydrazino)-p-toluamide (MIH). (30590)." Proc Soc Exp Biol Med 120 (1965): 561-5
Gillman PK "Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity." Br J Anaesth (2005):
Pettinger WA, Soyangco FG, Oates JA "Inhibition of monoamine oxidase in man by furazolidone." Clin Pharmacol Ther 9 (1968): 442-7
Nierenberg DW, Semprebon M "The central nervous system serotonin syndrome." Clin Pharmacol Ther 53 (1993): 84-8
"Product Information. Nucynta (tapentadol)." PriCara Pharmaceuticals, Raritan, NJ.
Sternbach H "The serotonin syndrome." Am J Psychiatry 148 (1991): 705-13
Martin TG "Serotonin syndrome." Ann Emerg Med 28 (1996): 520-6
Corkeron MA "Serotonin syndrome - a potentially fatal complication of antidepressant therapy." Med J Aust 163 (1995): 481-2
Mills KC "Serotonin syndrome: A clinical update." Crit Care Clin 13 (1997): 763
Darcy PF, Griffin JP "Interactions with drugs used in the treatment of depressive illness." Adverse Drug React Toxicol Rev 14 (1995): 211-31
Fischer P "Serotonin syndrome in the elderly after antidepressive monotherapy." J Clin Psychopharmacol 15 (1995): 440-2
Bodner RA, Lynch T, Lewis L, Kahn D "Serotonin syndrome." Neurology 45 (1995): 219-23
Staufenberg EF, Tantam D "Malignant hyperpyrexia syndrome in combined treatment." Br J Psychiatry 154 (1989): 577-8

Selegiline

Generic Name: selegiline

Brand name: Eldepryl, Zelapar, Emsam

Synonyms: n.a.

What is Selegiline?

Tapentadol

Generic Name: tapentadol

Brand name: Nucynta, Nucynta ER

Synonyms: n.a.

What is Tapentadol?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions