Selegiline and Tranylcypromine Sulfate

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using tranylcypromine together with selegiline is not recommended. Combining these medications may increase the risk of a hypertensive crisis, which is a life-threatening side effect associated with dangerously high blood pressure caused by consuming certain foods or beverages that are high in tyramine content (e.G., air dried, aged, or fermented meats; sausage or salami; pickled herring; anchovies; liver; red wine; beer; aged cheeses; sour cream; sauerkraut; canned figs; raisins; overly ripened bananas or avocados; soy beans; soy sauce; tofu; bean curds; fava beans; yeast extracts). In addition, you may have an increased risk of developing a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Severe cases may result in coma and even death. You should wait at least 14 days after stopping one medication before starting treatment with the other. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Coadministration of a selective monoamine oxidase B (MAO-B) inhibitor with other MAO inhibitors, selective or nonselective, may increase the risk of a hypertensive crisis. Although selective inhibitors of MAO-B presumably have minimal effect on intestinal and hepatic MAO-A that catabolizes exogenous amines like tyramine, the selectivity may not be absolute even at recommended doses and may diminish with increasing doses. Rare cases of hypertensive reactions associated with ingestion of tyramine-containing foods have been reported in patients taking the recommended daily dose of selegiline. There have also been postmarketing reports of patients who experienced significantly elevated blood pressure, including very rare cases of hypertensive crisis, after ingestion of unknown amounts of tyramine-rich foods while taking recommended doses of rasagiline, despite results from multiple tyramine challenge studies demonstrating selectivity for MAO-B at recommended doses. The combination of a selective MAO-B inhibitor and a nonselective MAO inhibitor can also cause hypotensive reactions including orthostasis. Hypotension, sometimes sudden in onset, has been reported with rasagiline and selegiline, particularly when used with levodopa and during the first two months of treatment.

CONTRAINDICATED: Coadministration of a selective MAO-B inhibitor with other MAO inhibitors may increase the risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A and 2A receptors. Symptoms of the serotonin syndrome may include mental status changes such as irritability, altered consciousness, confusion, hallucination, and coma; autonomic dysfunction such as tachycardia, hyperthermia, diaphoresis, shivering, blood pressure lability, and mydriasis; neuromuscular abnormalities such as hyperreflexia, myoclonus, tremor, rigidity, and ataxia; and gastrointestinal symptoms such as abdominal cramping, nausea, vomiting, and diarrhea.

MANAGEMENT: Concurrent use of selective MAO-B inhibitors with other MAO inhibitors is considered contraindicated. At least 14 days should elapse between discontinuation of a nonselective MAO inhibitor and initiation of treatment with a selective MAO inhibitor, and vice versa. The recommended dosages of selective MAO-B inhibitors should not be exceeded, as it can increase the risk of nonselective MAO inhibition and precipitation of a hypertensive crisis.

Selegiline

Generic Name: selegiline

Brand name: Eldepryl, Zelapar, Emsam

Synonyms: n.a.

What is Selegiline?

Tranylcypromine Sulfate

Generic Name: tranylcypromine

Brand name: Parnate

Synonyms: Tranylcypromine

What is Tranylcypromine Sulfate?