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Septra and Valcyte

Determining the interaction of Septra and Valcyte and the possibility of their joint administration.

Check result:

Septra <> Valcyte

Relevance: 14.02.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

The coadministration of ganciclovir or its prodrug, valganciclovir, with trimethoprim may result in elevated plasma concentrations of ganciclovir. In 12 subjects with HIV and CMV coinfection, trimethoprim (200 mg orally once a day) increased the half-life of ganciclovir (1000 mg orally every 8 hours) by an average of 15% and decreased its renal clearance by 16%. The mechanism is unknown but may involve the competitive inhibition of ganciclovir renal tubular secretion by trimethoprim. Ganciclovir had minimal effect on the pharmacokinetics of trimethoprim. This interaction is unlikely to be of clinical significance. . However, the use of ganciclovir with other potentially myelotoxic drugs such as trimethoprim may increase the risk and severity of these adverse events due to additive pharmacodynamic effects. The potential for this effect should be kept in consideration and the patient monitored for hematologic adverse effects.

References

"Product Information. Valcyte (valganciclovir)" Roche Laboratories, Nutley, NJ.
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0
"Product Information. Cytovene (ganciclovir)." Genentech, South San Francisco, CA.

Septra

Generic Name: sulfamethoxazole / trimethoprim

Brand name: Septra, Septra DS, Bactrim, Bactrim DS, Bactrim IV, Septra IV, SMZ-TMP DS, Sulfatrim Pediatric, Sulfatrim, Bethaprim, Cotrim, Uroplus, Uroplus DS, Cotrim DS, Bactrim Pediatric, Bethaprim Pediatric, Sulfatrim Suspension, Cotrim Pediatric

Synonyms: n.a.

What is Septra?

Valcyte

Generic Name: valganciclovir

Brand name: Valcyte

Synonyms: n.a.

What is Valcyte?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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