Sertraline Oral Liquid and Symtuza
Determining the interaction of Sertraline Oral Liquid and Symtuza and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using darunavir together with sertraline can decrease the effects of sertraline. Contact your doctor if your condition worsens. You may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with ritonavir- or cobicistat-boosted darunavir may decrease the plasma concentrations of sertraline. The mechanism of interaction has not been described. In 13 study subjects, administration of sertraline (50 mg once a day) in combination with darunavir/ritonavir (400 mg/100 mg twice a day) reduced the peak plasma concentration (Cmax), area under the concentration-time curve (AUC), and trough plasma concentration (Cmin) of sertraline by approximately one-half compared to administration without darunavir/ritonavir. Sertraline had no significant effect on the pharmacokinetics of darunavir.
MANAGEMENT: Patients treated concomitantly with ritonavir- or cobicistat-boosted darunavir may have diminished clinical response to sertraline. Pharmacologic response to sertraline should be monitored more closely whenever darunavir-ritonavir or darunavir-cobicistat is added to or withdrawn from therapy in patients stabilized on their existing antidepressant regimen, and the sertraline dosage adjusted as necessary.
- "Product Information. Prezista (darunavir)." Ortho Biotech Inc, Bridgewater, NJ.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
Generic Name: sertraline
Brand name: Zoloft
Synonyms: Sertraline
Generic Name: cobicistat / darunavir / emtricitabine / tenofovir alafenamide
Brand name: Symtuza
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Sertraline Oral Liquid-Synalar
- Sertraline Oral Liquid-Synalar (Fluocinolone Cream and Ointment)
- Sertraline Oral Liquid-Synalar (Fluocinolone Solution)
- Sertraline Oral Liquid-Synalar Mild
- Sertraline Oral Liquid-Synalar Ointment
- Sertraline Oral Liquid-Synalar Regular
- Symtuza-Sertraline Oral Solution
- Symtuza-Sertraline Tablets
- Symtuza-Servira
- Symtuza-Serzone
- Symtuza-Setlakin
- Symtuza-SetonET