Setlakin and Zelapar
Determining the interaction of Setlakin and Zelapar and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using selegiline together with ethinyl estradiol may increase the effects of selegiline. Contact your doctor if you experience severe headache, hallucinations, vision problems, sweating, cool or clammy skin, fast or uneven heart rate, feeling light-headed, fainting, or seizure (convulsions). If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: The use of oral contraceptives or hormone replacement therapy may significantly increase selegiline bioavailability. In one study, the AUC of selegiline increased by 10 to 20-fold in subjects taking oral contraceptives. The proposed mechanism is inhibition of CYP450 3A hepatic metabolism. Increased concentrations of selegiline may result in loss of MAO-B selectivity and potentially severe adverse effects such as the serotonin syndrome.
MANAGEMENT: Monitoring for signs and symptoms of selegiline toxicity such as excessive MAO inhibition and hypertension when female sex steroids are added and monitoring for reduced selegiline effectiveness when steroids are withdrawn is recommended. Selegiline dosage and dietary adjustments (avoiding tyramine) may be required. Patients should be advised to notify their physician promptly if they experience symptoms such as severe headache, dizziness, nervousness, weakness, irritability, altered consciousness, seizures, confusion, ataxia, abdominal cramping, hyperpyrexia, shivering, pupillary dilation, diaphoresis, or tachycardia.
- Laine K, Anttila M, Helminen A, Karnani H, Huupponen R "Dose linearity study of selegiline pharmacokinetics after oral administration: evidence for strong drug interaction with female sex steroids." Br J Clin Pharmacol 47 (1999): 249-54
Generic Name: ethinyl estradiol / levonorgestrel
Brand name: Afirmelle, Altavera, Amethia, Amethia Lo, Amethyst, Ashlyna, Aubra, Aubra EQ, Aviane, Ayuna, Balcoltra, Camrese, Camrese Lo, Chateal, Chateal EQ, Daysee, Delyla, Enpresse-28, FaLessa, Falmina, Fayosim, Introvale, Jolessa, Kurvelo, Larissia, Lessina, Levonest, Levora 015/30, Lillow, LoSeasonique, Lutera, Marlissa, Myzilra, Orsythia, Portia-28, Quartette, Quasense, Rivelsa, Seasonique, Setlakin, Simpesse, Sronyx, Trivora, Vienva, Alesse, Enpresse, Levlen, Levora, Lybrel, Nordette, Portia, Tri-Levlen, Triphasil-21, Triphasil-28, Trivora-28, Seasonale, Preven EC, Triphasil
Synonyms: n.a.
Generic Name: selegiline
Brand name: Eldepryl, Zelapar, Emsam
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.