Signifor LAR Injection and Tranylcypromine Sulfate

• Generic Name: pasireotide
• Dosage Forms: injection
• Other Brand Names: Signifor, Signifor LAR

Signifor LAR is a man-made protein that is similar to a hormone in the body called somatostatin.

Signifor LAR is used to treat Cushing's disease or acromegaly (endocrine disorders). This medicine is usually given after surgery or other treatments did not work or have stopped working.

Signifor LAR may also be used for purposes not listed in this medication guide.

• Generic Name: tranylcypromine
• Dosage Forms: n.a.
• Other Brand Names: Parnate

Treatment of major depressive disorder without melancholia.

Efficacy in major depressive disorder with melancholia (endogenous features) not established.

MAO inhibitors appear particularly effective in treatment of major depressive disorder with atypical features, although other antidepressants (e.g., SSRIs) may initially be used because of their more favorable adverse effect profile.

Because of potential for serious adverse effects and necessity of dietary restrictions, MAO inhibitors (e.g., phenelzine, tranylcypromine) generally are not used as initial therapy for major depressive disorder, but are reserved for carefully selected patients who can be closely supervised and who have depression refractory to other antidepressants (e.g., SSRIs, SNRIs, TCAs) or in whom other therapies are contraindicated.