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Silenor and Tagamet HB

Determining the interaction of Silenor and Tagamet HB and the possibility of their joint administration.

Check result:

Silenor <> Tagamet HB

Relevance: 16.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using cimetidine together with doxepin can increase the levels of doxepin. Contact your doctor if you experience excessive doxepin effects. This can include dry mouth, blurry vision, irregular or fast heartbeat, constipation, urinary retention, or extreme drowsiness. This can also cause dizziness or feeling like you might pass out, especially when getting up from a sitting or lying position. You may need a dose adjustment or special tests to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Cimetidine may increase the serum concentration of tricyclic antidepressants (TCAs) to toxic levels in some patients. The mechanism may be related to inhibition of CYP450 hepatic metabolism of TCAs.

MANAGEMENT: Close monitoring for clinical response and tolerance is recommended whenever cimetidine is added to or discontinued from a TCA regimen. Patients should be advised to notify their physician if they experience excessive TCA effects such as dry mouth, blurry vision, irregular or fast heartbeat, constipation, urinary retention, dizziness, or orthostatic hypotension. Lower doses of tricyclic antidepressants may be necessary. Ranitidine, famotidine, and nizatidine are not expected to interact and may be an alternative to cimetidine in this circumstance.

References

Wells BG, Pieper JA, Self TH, et al "The effect of ranitidine and cimetidine on imipramine disposition." Eur J Clin Pharmacol 31 (1986): 285-90
Abernethy DR, Greenblatt DJ, Shader RI "Imipramine-cimetidine interaction: impairment of clearance and enhanced absolute bioavailability." J Pharmacol Exp Ther 229 (1984): 702-5
Sutherland DL, Remillard AJ, Haight KR, Brown MA, Old L "The influence of cimetidine versus ranitidine on doxepin pharmacokinetics." Eur J Clin Pharmacol 32 (1987): 159-64
Henauer SA, Hollister LE "Cimetidine interaction with imipramine and nortriptyline." Clin Pharmacol Ther 35 (1984): 183-7
Miller DD, Macklin M "Cimetidine-imipramine interaction: a case report." Am J Psychiatry 140 (1983): 351-2
Curry SH, DeVane CL, Wolfe MM "Lack of interaction of ranitidine with amitriptyline." Eur J Clin Pharmacol 32 (1987): 317-20

Silenor

Generic Name: doxepin

Brand name: Silenor, Sinequan, Sinequan

Synonyms: n.a.

What is Silenor?

Tagamet HB

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: n.a.

What is Tagamet HB?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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