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Silenor and Thioridazine

Determining the interaction of Silenor and Thioridazine and the possibility of their joint administration.

Check result:

Silenor <> Thioridazine

Relevance: 16.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using doxepin together with thioridazine is not recommended. This can increase the effects of either medication. Call your doctor if you have side effects such as extreme drowsiness, confusion, agitation, vomiting, blurred vision, feeling hot or cold, sweating, muscle stiffness, fainting, seizure (convulsions), or coma. Using these medications together can also cause uncontrollable movements of the mouth, tongue, cheeks, jaw, arms, or legs, fever, muscle rigidity, irregular pulse, or fast or irregular heartbeats. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: Coadministration of thioridazine with another phenothiazine or a tricyclic antidepressant (TCA) may result in elevated plasma concentrations of both drugs. Most phenothiazines and TCAs have been found to undergo metabolism by CYP450 2D6, thus competitive inhibition of the enzyme may occur when more than one of these agents are administered. The possibility of an increased risk of serious adverse effects such as central nervous system depression, hypotension, and arrhythmia should be considered. In addition, these agents individually can cause prolongation of the QT interval, thus concomitant administration may result in elevated risk of ventricular arrhythmias including ventricular tachycardia and torsade de pointes.

MANAGEMENT: The use of thioridazine with drugs that can inhibit CYP450 2D6 and/or prolong the QT interval is considered contraindicated.

References

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Silenor

Generic Name: doxepin

Brand name: Silenor, Sinequan, Sinequan

Synonyms: n.a.

What is Silenor?

Thioridazine

Generic Name: thioridazine

Brand name: Mellaril, Mellaril-S

Synonyms: n.a.

What is Thioridazine?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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