Silenor and Xylometazoline nasal

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this interaction is not currently available.MONITOR: Coadministration with tri- or tetra-cyclic antidepressants may theoretically potentiate the sympathomimetic effects (e.g., hypertension, tachycardia) of systemically absorbed xylometazoline following topical (i.e., nasal) administration. The proposed mechanism may involve additive or synergistic increases in circulating catecholamines, such as noradrenaline (norepinephrine). MANAGEMENT: Until further information is available, caution is advised if a tri- or tetra-cyclic antidepressant is used concomitantly with topical xylometazoline. Blood pressure and heart rate should be monitored at regular intervals during concomitant therapy. A dose reduction or discontinuation of concomitant therapy should be considered in patients who experience a sustained increase in blood pressure or heart rate. References Agencia Española de Medicamentos y Productos Sanitarios Healthcare "Centro de información online de medicamentos de la AEMPS - CIMA. Available from: URL: https://cima.aemps.es/cima/publico/home.html." ([2018]): Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

MONITOR: Coadministration with tri- or tetra-cyclic antidepressants may theoretically potentiate the sympathomimetic effects (e.g., hypertension, tachycardia) of systemically absorbed xylometazoline following topical (i.e., nasal) administration. The proposed mechanism may involve additive or synergistic increases in circulating catecholamines, such as noradrenaline (norepinephrine).

MANAGEMENT: Until further information is available, caution is advised if a tri- or tetra-cyclic antidepressant is used concomitantly with topical xylometazoline. Blood pressure and heart rate should be monitored at regular intervals during concomitant therapy. A dose reduction or discontinuation of concomitant therapy should be considered in patients who experience a sustained increase in blood pressure or heart rate.

Silenor

Generic Name: doxepin

Brand name: Silenor, Sinequan, Sinequan

Synonyms: n.a.

What is Silenor?

Xylometazoline nasal

Generic Name: xylometazoline nasal

Brand name: Triaminic Decongestant, Otrivin

Synonyms: n.a.

What is Xylometazoline nasal?