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Silenor and Yohimbine

Determining the interaction of Silenor and Yohimbine and the possibility of their joint administration.

Check result:
Silenor <> Yohimbine
Relevance: 16.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using doxepin together with yohimbine. Using doxepin with yohimbine can increase the blood levels or add to the side effects of yohimbine. This may cause dizziness or other mental status changes. Use caution when rising from a sitting or lying position and when driving, operating machinery, or performing other hazardous activities. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Some antidepressants such as the tricyclics may potentiate the pressor effect of yohimbine. The mechanism is a synergistic sympathomimetic effect due to stimulation of norepinephrine release by yohimbine and inhibition of norepinephrine reuptake by certain antidepressants.

MANAGEMENT: Yohimbine should be avoided in patients undergoing concurrent treatment with tricyclic antidepressants or other drugs that interfere with neuronal uptake or metabolism of norepinephrine.

References
  • Fugh-Berman A "Herb-drug interactions." Lancet 355 (2000): 134-8
  • Mansoor GA "Herbs and alternative therapies in the hypertension clinic." Am J Hypertens 14(9 Pt 1) (2001): 971-5
  • "Product Information. Yocon (yohimbine)." Glenwood Inc, Tenafly, NJ.
Silenor

Generic Name: doxepin

Brand name: Silenor, Sinequan, Sinequan

Synonyms: n.a.

Yohimbine

Generic Name: yohimbine

Brand name:

Synonyms: Yohimbine (Oral)

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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